Handbook of Basic Pharmacokinetics

Including Clinical Applications, 7th Edition

by Wolfgang A. Ritschel, Gregory L. Kearns

Copyright    Dedication    Preface    Authors   
Chapter 1. Definitions and Nomenclature
Chapter 2. The LADMER System: Liberation, Absorption, Distribution, Metabolism, Elimination, and Response
Chapter 3. Organs, Tissues, Cells, and Organelles
Chapter 4. Cell Membranes
Chapter 5. Drug–Receptor Interactions
Chapter 6. Absorption/Transport Mechanisms
Chapter 7. pKa and Degree of Ionization
Chapter 8. Lipid/Water Partition Coefficient
Chapter 9. Physicochemical and Biological Factors Affecting In Vivo Performance of Drugs
Chapter 10. Biopharmaceutical Data on the Gastrointestinal Tract
Chapter 11. Fluid Compartments and Circulatory System
Chapter 12. Binding of Drugs to Biological Material
Chapter 13. Drug Biotransformation
Chapter 14. Compartment Models
Chapter 15. Determination of Rate Constants
Chapter 16. Volume of Distribution and Distribution Coefficient
Chapter 17. Excretion and Clearance of Drugs
Chapter 18. Urinary and Biliary Recycling
Chapter 19. Cumulative Urinary Excretion
Chapter 20. Area Under the Blood Level–Time Curve
Chapter 21. Pharmacokinetics of Single-Dose Administration
Chapter 22. Pharmacokinetics of Multiple Dosing
Chapter 23. Compartment-Model-Independent Analysis
Chapter 24. Pediatric Pharmacokinetics
Chapter 25. Drug Dosage in Elderly Patients
Chapter 26. Drug Dosage in Obese Patients
Chapter 27. Drug Disposition in Pregnancy
Chapter 28. Dosage Regimen Design
Chapter 29. Drug Monitoring and Dose Adjustment
Chapter 30. Physiologic and Pathologic Factors Influencing Drug Response
Chapter 31. First-Dose Size in Man
Chapter 32. Forensic Pharmacokinetics
Chapter 33. Nonlinear Pharmacokinetics
Chapter 34. Curve Fitting
Chapter 35. Correlation of Clinical Response with Drug Disposition
Chapter 36. Bioavailability and Bioequivalence
Chapter 37. Body Surface Areas
Chapter 38. Extracorporeal Methods of Drug Removal
Chapter 39. Pharmacogenetics and Pharmacogenomics
Appendix: Pharmacokinetic Parameters of Important Drugs