Synaptic Transmission in Seizure Disorder 

DP is a 24-year-old male who had his first tonic–clonic seizure at the age of 15. At the beginning of the seizure, this patient experiences an immediate loss of consciousness and often incontinence. A common disorder encountered in pediatric neurology, this form of seizure begins with sharp tonic contraction of the muscles characterized by extension of the extremities. This is followed by the clonic phase which is characterized by rhythmic bilateral contraction and relaxation